Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells
| Autor: | Jiqin Zhang, Xingmo Liu, Jialin Su, Zhenhua Lin, Weidong Ji, Jianan He, Shuai Huang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases Cancer Research Cell disabled homolog 2 interactive protein Biology cell migration and invasion 03 medical and health sciences 0302 clinical medicine osteosarcoma medicine Oncogene Cell growth Cell migration Osteoblast Articles Cell cycle medicine.disease 030104 developmental biology medicine.anatomical_structure cell proliferation Oncology Cell culture 030220 oncology & carcinogenesis Cancer research Osteosarcoma |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | The disabled homolog 2 interactive protein (DAB2IP) gene is a member of the family of Ras GTPases and functions as a tumor suppressor in many types of carcinoma; however, its function in osteosarcoma remains unclear. The aim of the present study was to determine the function of DAB2IP in osteosarcoma and normal bone cells in vitro. The expression of DAB2IP protein was assessed in osteoblast and osteosarcoma cell lines by western blot analysis. The effects of DAB2IP expression on cell proliferation, colony formation, apoptosis, cell cycle, and cell migration and invasion were evaluated by in vitro studies. DAB2IP expression was lower in osteosarcoma cell lines than in normal osteoblast cell lines. DAB2IP expression affected cell proliferation, apoptosis and cell cycle distribution. In addition, DAB2IP inhibited the migration and invasion of osteosarcoma and normal osteoblast cells. Therefore, DAB2IP may function as a tumor suppressor in osteosarcoma cell lines by inhibiting cell proliferation and invasion. |
| Databáze: | OpenAIRE |
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