Intestinal ultrasound for monitoring therapeutic response in patients with ulcerative colitis: results from the TRUST&UC study
| Autor: | Christian, Maaser, Frauke, Petersen, Ulf, Helwig, Imma, Fischer, Alexander, Roessler, Stefan, Rath, Dorothee, Lang, Torsten, Kucharzik, Joachim, Weber-Guskar |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pancolitis Anti-Inflammatory Agents Proctosigmoiditis Gastroenterology Inflammatory bowel disease Disease-Free Survival Descending colon 03 medical and health sciences 0302 clinical medicine Colon Sigmoid Germany Internal medicine Secondary Prevention medicine Humans Prospective Studies Ultrasonography Doppler Color Colitis Monitoring Physiologic business.industry Remission Induction Ultrasound Sigmoid colon medicine.disease Ulcerative colitis Colon Descending 030104 developmental biology medicine.anatomical_structure Colitis Ulcerative Female 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Gut. 69:1629-1636 |
| ISSN: | 1468-3288 0017-5749 |
| DOI: | 10.1136/gutjnl-2019-319451 |
| Popis: | ObjectiveProspective evaluation of intestinal ultrasound (IUS) for disease monitoring of patients with ulcerative colitis (UC) in routine medical practice.DesignTRansabdominal Ultrasonography of the bowel in Subjects with IBD To monitor disease activity with UC (TRUST&UC) was a prospective, observational study at 42 German inflammatory bowel disease-specialised centres representing different care levels. Patients with a diagnosis of a proctosigmoiditis, left-sided colitis or pancolitis currently in clinical relapse (defined as Short Clinical Colitis Activity Index ≥5) were enrolled consecutively. Disease activity and vascularisation within the affected bowel wall areas were assessed by duplex/Colour Doppler ultrasonography.ResultsAt baseline, 88.5% (n=224) of the patients had an increased bowel wall thickness (BWT) in the descending or sigmoid colon. Even within the first 2 weeks of the study, the percentage of patients with an increased BWT in the sigmoid or descending colon decreased significantly (sigmoid colon 89.3%–38.6%; descending colon 83.0%–42.9%; pConclusionsIUS may be preferred in general practice in a point-of-care setting for monitoring the disease course and for assessing short-term treatment response. Our findings give rise to the assumption that monitoring BWT alone has the potential to predict the therapeutic response, which has to be verified in future studies. |
| Databáze: | OpenAIRE |
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