Combined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection
| Autor: | Malik Peiris, Leo L.M. Poon, Li-Meng Yan, Sophie A. Valkenburg, Ranawaka A.P.M. Perera, Olive T. W. Li, Chek M. Poh |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
viruses Biology Vaccines Attenuated medicine.disease_cause Article Virus Mice 03 medical and health sciences chemistry.chemical_compound Orthomyxoviridae Infections Virology Pandemic Influenza A virus medicine Animals Antigens Viral Heterosubtypic immunity Mice Inbred BALB C virus diseases Influenza A virus subtype H5N1 Vaccination 030104 developmental biology Vaccines Inactivated Immunization chemistry Influenza Vaccines Female Vaccinia |
| Zdroj: | Virology. 525:73-82 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2018.09.007 |
| Popis: | The limited protection of current commerical vaccines necessitates the investigation of novel vaccine strategies for unpredictable outbreaks. To investigate the feasibility of using vaccines derived from Group 1 influenza A virus to induce broadly cross-reactive immune responses against multiple influenza subtypes, we tested a panel of sequential 4-dose immunization regimens in mice. Mice were treated with inactivated (seasonal H1N1, pandemic H1N1 and H5N1) and vaccinia virus-based H5N1 live-attenuated vaccines in different combinations. Mice were then challenged by viruses of either Group 1 (H1N1) or Group 2 (H3N2, H7N7) influenza virus. All studied sequential 4-dose vaccinations could induce some degrees of heterosubtypic protection in mice. Amongst all these regimens, the combined use of inactivated and live-attenuated vaccines could achieve the best heterologous protection. These results highlight the synergistic effect of combining different vaccine platforms to enhance heterosubtypic protection against influenza viruses. |
| Databáze: | OpenAIRE |
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