Genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumours of the central nervous system
| Autor: | C. Perot, Juan A. Rey, M. Guillaud-Bataille, G. Danglot, Xing Fan, M. M. Inda, M. J. Bello, Charles G. Eberhart, Teresa Tuñón, Idoya Zazpe, Javier S. Castresana, E. Portillo, A. Bernheim, José María Martínez-Peñuela |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Pathology Histology Central nervous system Isochromosome Infratentorial Neoplasms Biology Pathology and Forensic Medicine Genetic Heterogeneity Supratentorial PNET medicine Humans Neuroectodermal Tumors Primitive Medulloblastoma Brain Neoplasms Chromosomes Human Pair 10 Genetic heterogeneity Nucleic Acid Hybridization Supratentorial Neoplasms Chromosome Anatomical pathology General Medicine medicine.disease medicine.anatomical_structure Chromosomes Human Pair 1 Chromosomes Human Pair 4 Chromosomes Human Pair 19 Chromosomes Human Pair 16 Chromosomes Human Pair 7 Chromosomes Human Pair 17 Comparative genomic hybridization |
| Zdroj: | Histopathology. 47:631-637 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1111/j.1365-2559.2005.02304.x |
| Popis: | Aims : Medulloblastoma (MB), a kind of infratentorial primitive neuroectodermal tumour (PNET), is the most frequent malignant brain tumour in childhood. In contrast, supratentorial PNET (sPNET) are very infrequent tumours, but they are histologically similar to MB, although they present a worse clinical outcome. We investigated the differences in genetic abnormalities between sPNET and MB. Methods and results : We analysed 20 central PNET (14 MB and six sPNET) by conventional comparative genomic hybridization (CGH) in order to determine whether a different genetic profile for each tumour exists. Isochromosome 17q was detected in four of the 14 MB cases, but not in any sPNET. Gains at 17q and 7 happened more frequently in MB, and those at 1q in sPNET. Losses at chromosome 10 were detected only in MB, while losses at 16p and 19p happened more frequently in sPNET. A new amplification site, on 4q12, was detected in two MB. Conclusions : Central PNET are a heterogeneous group of tumours from the genetic point of view. The present and previous data, together with further results from larger series, might contribute to the establishment of specific treatments for supratentorial and infratentorial PNET. |
| Databáze: | OpenAIRE |
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