Effect of 5-HTP and L-Dopa on lipid profile of Streptozotocin induced diabetic mice
| Autor: | Rajkumari Batham, Ulka Yadav |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Female Albino mice medicine.medical_treatment Blood sugar Blood lipids Biology chemistry.chemical_compound Internal medicine Diabetes mellitus medicine GE1-350 medicine.diagnostic_test Triglyceride L-Dopa Insulin Diabetes Streptpzotocin Streptozotocin medicine.disease 5-HTP Environmental sciences Endocrinology chemistry lipids (amino acids peptides and proteins) Hemoglobin Lipid profile medicine.drug |
| Zdroj: | Environment Conservation Journal, Vol 15, Iss 3 (2014) |
| ISSN: | 2278-5124 0972-3099 |
| Popis: | The present study was designed to test whether the precursor of serotonin (i.e.5-HTP) and dopamine (i.e. L-DOPA) can influence Body weight and certain hematological constitutes (i.e. blood glucose, glycosylated hemoglobin and serum protein) in streptozotocin induced diabetic mice. In the study, animals were divided into 6 groups. After 10 days at the termination of experiment body weight and blood glucose taken. Blood was collected from left ventricle and deposited to pathology for haematological analysis (i.e. blood Glucose, glycosylated heamoglobin, serum protein, triglyceride total cholesterol, HDL-cholesterol, LDC-cholesterol, and VLDL-cholesterol). Statistical analysis were done with the help of student’s ‘t’ test followed by analysis of variance (ANOVA). The result of the present study suggest that peripheral administration of 5-HTP (a precursor of serotonin) and L-DOPA (a precursor of dopamine) influences the body weight gain and lipid profile (i.e. triglyceride, total cholesterol, HDL-cholesterol , LDL-Cholesterol, VLDC-cholesterol) in streptozotocin induce diabetic mice. The finding of the present study supports the concept that insulin alone does not fully control diabetes. Other chemical substance like neurotransmitter/hormones may involve in controlling the diabetes. |
| Databáze: | OpenAIRE |
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