Homologous collagen-induced arthritis in rats and mice are associated with structurally different major histocompatibility complex DQ-like molecules
| Autor: | T J Goldschmidt, Rikard Holmdahl, Kenth Gustafsson, Hans J. Hedrich, Carina Vingsbo, Christina Kvick, Mikael Karlsson |
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| Rok vydání: | 1992 |
| Předmět: |
musculoskeletal diseases
Immunology Antigen presentation Genes MHC Class II Molecular Sequence Data Type II collagen Congenic Arthritis macromolecular substances Biology Major histocompatibility complex Article Major Histocompatibility Complex Mice medicine Immunology and Allergy Animals Amino Acid Sequence skin and connective tissue diseases Peptide sequence Genetics Base Sequence Haplotype T-cell receptor Histocompatibility Antigens Class II Articles medicine.disease Arthritis Experimental Rats Haplotypes Oligodeoxyribonucleotides biology.protein Collagen |
| Zdroj: | European Journal of Immunology |
| ISSN: | 0014-2980 |
| Popis: | Collagen‐induced arthritis (CIA) in rats, induced with homologous type II collagen (CII), is a genetically more restricted disease and has better resemblance to rheumatoid arthritis by its chronic disease course, than CIA induced with heterologous CII. The DA strain is highly susceptible to CIA induced with homologous CII, while the Lewis strain is resistant. (DAxLew)F1 is susceptible and backcrossing to Lewis reveals a close, but not complete, association of both arthritis and CII responsiveness to the RT1a haplotype. Analyses of congenic strains on DA and Lewis backgrounds suggest that expression of a major histocompatibility complex class II Ba molecule, encoded from the RT1Ba locus, is associated with arthritis susceptibility and CII responsiveness. The second exons coding for the first domains of the α and β chains of both the RT1a and RT11 haplotypes were sequenced and the deduced amino acid sequences compared with the corresponding molecule associated with susceptibility to CIA in the mouse (H‐2 Aq). The sequences of the respective alleles revealed no obvious structural homology explaining the extensive similarities in the development of chronic autoimmune arthritis. Instead, this finding implies that different trimolecular constituents (i.e. class II,T cell receptor, and CII peptides) may yield an antigen presentation event that is able to trigger a similar autoaggressiveness in the two rodent species. |
| Databáze: | OpenAIRE |
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