LncRNA FABP5P3/miR-589-5p/ZMYND19 axis contributes to hepatocellular carcinoma cell proliferation, migration and invasion
| Autor: | Yong Ni, Qian Zhu, Guiyu Lu, Jinghua Wu, Fenfang Gui, Zihua Luo, Faming Li |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Carcinoma Hepatocellular Biophysics Mice Nude Hepatic carcinoma Biology Biochemistry law.invention 03 medical and health sciences 0302 clinical medicine law Cell Movement Cell Line Tumor medicine Animals Humans Neoplasm Invasiveness neoplasms Molecular Biology Survival rate Cell Proliferation Messenger RNA Mice Inbred BALB C Cell growth Liver Neoplasms Cell Biology medicine.disease digestive system diseases Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Cell culture 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Disease Progression Suppressor RNA Long Noncoding Carrier Proteins Signal Transduction |
| Zdroj: | Biochemical and biophysical research communications. 498(3) |
| ISSN: | 1090-2104 |
| Popis: | Hepatocellular carcinoma (HCC) contributes to cancer-related deaths greatly every year in the world. However, there is still no radical method for HCC treatment. Here we screened out a lncRNA FABP5P3 that was up-regulated in HCC tissues. Patients with higher FABP5P3 expression displayed poorer survival rate. FABP5P3 depletion in HCC cell lines and sample cells remarkably inhibited the abilities of proliferation, migration and invasion. In mechanism, we showed that FABP5P3 bond to miR-589-5p which served as a tumor suppressor. MiR-589-5p targeted directly the mRNA of ZMYND19 whose function has not been defined in HCC. FABP5P3 promoted HCC development and progression by sponging miR-589-5p and up-regulating ZMYND19 expression. In sum, we showed that FABP5P3/miR-589-5p/ZMYND19 axis regulates cell proliferation and migration in HCC, which may serve as a new target for HCC treatment. |
| Databáze: | OpenAIRE |
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