The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice
| Autor: | Jesper L. Kristensen, Anna U. Odland, Jesper T. Andreasen |
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| Rok vydání: | 2021 |
| Předmět: |
Agonist
medicine.drug_class Reversal Learning Anxiety Ligands Affect (psychology) Depressive Disorder Treatment-Resistant Mice Cognition medicine Animals Receptor Serotonin 5-HT2A Clinical efficacy Receptor Pharmacology Behavior Animal Human studies business.industry Cognitive flexibility 25CN-NBOH Mice Inbred C57BL Psychiatry and Mental health Treatment Outcome Hallucinogens medicine.symptom business Neuroscience Serotonin 5-HT2 Receptor Agonists |
| Zdroj: | Behavioural Pharmacology. 32:448-452 |
| ISSN: | 0955-8810 |
| Popis: | Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study. |
| Databáze: | OpenAIRE |
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