A novel receptor for Apo2L/TRAIL contains a truncated death domain
| Autor: | Arthur J Huang, A.D. Goddard, Avi Ashkenazi, Paulj. Godowski, Scot A. Marsters, R.M. Pitti, Daryl T. Baldwin, A. Gurney, M. Skubatch, Yuan Jean, James P. Sheridan |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
DNA Complementary Recombinant Fusion Proteins Molecular Sequence Data Apoptosis Biology Vascular endothelial growth inhibitor General Biochemistry Genetics and Molecular Biology Receptors Tumor Necrosis Factor TNF-Related Apoptosis-Inducing Ligand Humans Amino Acid Sequence fas Receptor Decoy receptors Receptor Death domain Cell Line Transformed Membrane Glycoproteins Agricultural and Biological Sciences(all) Base Sequence Sequence Homology Amino Acid Biochemistry Genetics and Molecular Biology(all) Tumor Necrosis Factor-alpha Ligand (biochemistry) Fas receptor Molecular biology Cell biology General Agricultural and Biological Sciences Apoptosis Regulatory Proteins Tumor Necrosis Factor Decoy Receptors Chromosomes Human Pair 8 HeLa Cells |
| Zdroj: | Current biology : CB. 7(12) |
| ISSN: | 0960-9822 |
| Popis: | Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the TNF family and activates apoptosis in tumor cells. Three closely related receptors bind Apo2L: DR4 and DR5, which contain cytoplasmic death domains and signal apoptosis, and DcR1, a decoy receptor that lacks a cytoplasmic tail and inhibits Apo2L function [3–5]. By cross-hybridization with DcR1, we have identified a fourth Apo2L receptor, which contains a cytoplasmic region with a truncated death domain. We subsequently named this protein decoy receptor 2 (DcR2). The DcR2 gene mapped to human chromosome 8p21, as did the genes encoding DR4, DR5 and DcR1. A single DcR2 mRNA transcript showed a unique expression pattern in human tissues and was particularly abundant in fetal liver and adult testis. Upon overexpression, DcR2 did not activate apoptosis or nuclear factor-κB; however, it substantially reduced cellular sensitivity to Apo2L-induced apoptosis. These results suggest that DcR2 functions as an inhibitory Apo2L receptor. |
| Databáze: | OpenAIRE |
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