Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries
| Autor: | Kristina Kjærheim, Jan Ivar Martinsen, Jorma Sormunen, Per Sparen, Madar Talibov, Elisabete Weiderpass, Laufey Tryggvadottir, Eero Pukkala, Johnni Hansen |
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| Přispěvatelé: | Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Department of Medical and Clinical Genetics, Faculty of Medicine, University of Helsinki |
| Rok vydání: | 2019 |
| Předmět: |
Diesel exhaust
Occupational cancer Kansanterveystiede ympäristö ja työterveys - Public health care science environmental and occupational health Case–control study Colorectal cancer Vinnustaðir complex mixtures OCCUPATIONAL-CANCER RATS Odds 03 medical and health sciences Diesel fuel 0302 clinical medicine COLON Syöpätaudit - Cancers Environmental health medicine COHORT 030212 general & internal medicine Workplace Safety Risk Reliability and Quality RECTAL-CANCER WORK Chemical Health and Safety Ristilkrabbamein VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health Case-control study lcsh:RA1-1270 medicine.disease 030210 environmental & occupational health 3142 Public health care science environmental and occupational health Olíumengun Confidence interval 3. Good health 13. Climate action Cohort Original Article HEALTH VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 business human activities Safety Research Gasoline |
| Zdroj: | Safety and Health at Work, Vol 10, Iss 2, Pp 141-150 (2019) |
| ISSN: | 2093-7911 |
| Popis: | Publisher's version (útgefin grein) Background: Evidence on associations between occupational diesel exhaust and gasoline exposure and colorectal cancer is limited. We aimed to assess the effect of workplace exposure to diesel exhaust and gasoline on the risk of colorectal cancer. Methods: This case–control study included 181,709 colon cancer and 109,227 rectal cancer cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden. Cases and controls were identified from the Nordic Occupational Cancer Study cohort and matched for country, birth year, and sex. Diesel exhaust and gasoline exposure values were assigned by country-specific job-exposure matrices. Odds ratios and 95% confidence intervals were calculated by using conditional logistic regression models. The results were adjusted for physical strain at work and occupational exposure to benzene, formaldehyde, ionizing radiation, chlorinated hydrocarbons, chromium, and wood dust. Results: Diesel exhaust exposure was associated with a small increase in the risk of rectal cancer (odds ratio = 1.05, 95% confidence interval 1.02-1.08). Gasoline exposure was not associated with colorectal cancer risk. Conclusion: This study showed a small risk increase for rectal cancer after workplace diesel exhaust exposure. However, this finding could be due to chance, given the limitations of the study. The authors thank the Nordic Occupational Cancer Studies (NOCCA) project members for the development of NOCCA cohort data and job-exposure matrix. |
| Databáze: | OpenAIRE |
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