Sodium/calcium exchanger in heart muscle: molecular biology, cellular function, and its special role in excitation-contraction coupling
| Autor: | Ernst Niggli, Robert S Kieval, Andrea Doering, Dan H. Schulze, R. W. Hadley, Mark S. Kirby, Paulo Kofuji, W. J. Lederer |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Calmodulin
Physiology Sodium Guinea Pigs Sarcoplasm chemistry.chemical_element 610 Medicine & health Calcium Sodium-Calcium Exchanger Dogs Physiology (medical) Animals Humans Ion transporter Sodium-calcium exchanger biology Chemistry Heart Myocardial Contraction Molecular biology Rats Reticular connective tissue biology.protein Carrier Proteins Cardiology and Cardiovascular Medicine Intracellular |
| Zdroj: | Schulze, Dan; Kofuji, Paulo; Hadley, Robert; Kirby, Mark S; Kieval, Robert S; Doering, Andrea; Niggli, Ernst; Lederer, W J (1993). Sodium/calcium exchanger in heart muscle: molecular biology, cellular function, and its special role in excitation-contraction coupling. Cardiovascular research, 27(10), pp. 1726-1734. Oxford University Press 10.1093/cvr/27.10.1726 Scopus-Elsevier Europe PubMed Central |
| Popis: | The Na/Ca exchanger has been examined with respect to its molecular biology, its cellular function, and its role in excitation-contraction coupling. The Na/Ca exchanger plays a central part in excitation-contraction coupling, setting the level of sarcoplasmic reticular calcium and contributing to the triggering of sarcoplasmic reticular calcium release. Functional biophysical studies with isolated single cells and caged calcium provide evidence that the Na/Ca exchanger works as a two step sequential transporter. In the heart there are about 250 exchangers.mu-2, operating at a turnover rate of up to about 2500.s-1, with the exchanger carrying -2.56 charges under normal conditions. The Na/Ca exchanger has been recently cloned from diverse mammalian species and several tissues and is largely conserved. It is clear, however, that the function of the Na/Ca exchanger is different in the different tissues. Thus work is in progress in several laboratories, including ours, to determine how the Na/Ca exchanger achieves its tissue specific function. Several modulatory motifs have been seen in studies of the exchanger that may explain some of the tissue specific differences. Interestingly the modulation of the Na/Ca exchanger (for example, by protons, sodium, calcium, ATP, calmodulin) seems to arise from interactions with the intracellular loop. |
| Databáze: | OpenAIRE |
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