Is Adrenal Ovarian Thecal Metaplasia a Misnomer? Report of Three Cases of Radial Scar-Like Spindle Cell Myofibroblastic Nodule of the Adrenal Gland
| Autor: | Simon J. Raphael, Amrah Pirzada, Sylvia L. Asa, Ozgur Mete |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Stromal cell Radial scar Endocrinology Diabetes and Metabolism Adrenal Gland Neoplasms Biology Pathology and Forensic Medicine Lesion Endocrinology Stroma Terminology as Topic Metaplasia medicine Humans Myofibroblasts Aged Adrenal gland Nodule (medicine) General Medicine Anatomy Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Theca Female medicine.symptom |
| Zdroj: | Endocrine Pathology. 22:222-225 |
| ISSN: | 1559-0097 1046-3976 |
| Popis: | Ovarian thecal metaplasia is a rare tumor-like mesenchymal lesion of the adrenal gland that has been reported mainly in postmenopausal women and rarely in men. It was originally described as a wedge-shaped lesion composed of ovarian-like stroma resembling theca that shows continuity with the capsule of the adrenal gland. We report three cases and identify that these lesions can resemble a radial scar. While a single case has been reported to contain true ovarian stromal elements, there was no evidence of steroidogenic differentiation in our cases. These findings justify the need for a better terminology since the entity falls within the spectrum of fibroblastic-myofibroblastic proliferations. We propose the terminology of "radial scar-like spindle cell myofibroblastic nodule of the adrenal gland" as a more accurate nomenclature to designate these lesions. Although rare, calcifying fibrous tumor of the adrenal gland, hypertrophic nerve bundles, and peripheral nerve sheath tumors may mimic these lesions. |
| Databáze: | OpenAIRE |
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