Oxygen Radical System in Chronic Infarcted Rat Heart: The Effect of Combined Beta Blockade and ACE Inhibition
| Autor: | Holger Scholz, Dietrich Romberg, Steffen Strube, Gert Baumann, Joachim Günther, Kay-Dietrich Wagner, Heinz Theres, Sabine Schulz, Kate P. Leiterer, Ingolf Schimke |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Ramipril Lipid Peroxides medicine.medical_specialty medicine.drug_class Adrenergic beta-Antagonists Myocardial Infarction Angiotensin-Converting Enzyme Inhibitors medicine.disease_cause Ventricular Function Left Lipid peroxidation chemistry.chemical_compound Internal medicine Animals Medicine Drug Interactions Rats Wistar Beta blocker Metoprolol Pharmacology chemistry.chemical_classification Glutathione Peroxidase Superoxide Dismutase business.industry Glutathione peroxidase Papillary Muscles medicine.disease Rats Isoenzymes Endocrinology chemistry Heart failure ACE inhibitor Reactive Oxygen Species Cardiology and Cardiovascular Medicine business Oxidative stress Muscle Contraction medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 35:708-715 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200005000-00005 |
| Popis: | In vitro experiments suggest that beta blockade and angiotensin-converting enzyme (ACE) inhibition may protect the failing heart by reduction of myocardial oxidative stress. To test this hypothesis in an in vivo model, the beta blocker metoprolol (350 mg) and the ACE inhibitor ramipril (1 mg) were given either alone or in combination to rats (per kilogram body weight per day) for 6 weeks after myocardial infarction. Left ventricular end-diastolic pressure (LVEDP), contractile function of papillary muscles, enzymatic antioxidative defense (indicated by the activities of the superoxide dismutase isoenzymes and glutathione peroxidase), and the extent of lipid peroxidation were studied. Placebo-treated rats showed cardiac hypertrophy, increased LVEDP, lower rates of contraction and relaxation, as well as a deficit in the myocardial antioxidative defense associated with increased lipid peroxide levels, when compared with sham-operated animals. Combined beta blockade and ACE inhibition improved the antioxidative defense, reduced hypertrophy and LVEDP, and enhanced rates of contraction. Thus prolonged beta blockade and ACE inhibition after infarction may decrease myocardial oxidative stress and thereby could be beneficial in heart failure. |
| Databáze: | OpenAIRE |
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