Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis

Autor: Ivana Z. Matić, Borivoj Bijelić, Zorica Juranić, Ljiljana Janković, Senka Marušić, Sladjana Andrejevic, Irina Besu
Rok vydání: 2019
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Systemic disease
Adolescent
Tissue transglutaminase
Immunology
Enzyme-Linked Immunosorbent Assay
Disease
Recurrent aphthous stomatitis
Inflammatory bowel disease
Gastroenterology
Gliadin
Antibodies
Antineutrophil Cytoplasmic
Young Adult
03 medical and health sciences
0302 clinical medicine
GTP-Binding Proteins
Internal medicine
medicine
Humans
Immunology and Allergy
Protein Glutamine gamma Glutamyltransferase 2
Aged
Anti-neutrophil cytoplasmic antibody
Transglutaminases
biology
business.industry
Mouth Mucosa
IIf
Hematology
Middle Aged
Inflammatory Bowel Diseases
medicine.disease
Immunoglobulin A
3. Good health
Celiac Disease
030104 developmental biology
biology.protein
Female
Stomatitis
Aphthous
Antibody
business
Biomarkers
030215 immunology
Zdroj: Immunobiology
ISSN: 0171-2985
Popis: The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadin-analogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and antineutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects. The prevalence of CeD specific antibodies did not differ between RAS patients and controls. However, the concentrations of IgA anti-tTG, IgA anti-GAF-3X antibodies in patients with RAS were significantly higher compared to controls (p = 0.002 and p = 0.04 respectively). Histological changes consistent with CeD were confirmed by duodenal biopsy in one RAS patient with highly positive IgA anti-tTG, anti-GAF-3X and anti-DGP antibodies. Higher prevalence along with higher concentrations of IgG ASCA were found in RAS patients compared to controls (p < 0.01). Patients with positive IgG ASCA in the absence of clinical symptoms decided not to pursue any further testing. Dysfunction of oral mucosa and the exposure to various antigens might be a reason for the loss of tolerance resulting in increased production of autoantibodies. It seems likely that antibodies are markers of aberrant immune response, rather than key effectors involved in the pathogenesis of the disease..
Databáze: OpenAIRE
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