Predictive value of pretreatment albumin‐to‐alkaline phosphatase ratio for overall survival for patients with advanced non‐small cell lung cancer
Autor: | Shaozhang Zhou, Ni Wei, Qitao Yu, Huilin Wang, Wei Jiang |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Cancer Research Lung Neoplasms NSCLC Gastroenterology Metastasis 0302 clinical medicine Carcinoma Non-Small-Cell Lung AAPR subgroup analysis Original Research Hazard ratio Age Factors Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Female China medicine.medical_specialty overall survival Subgroup analysis lcsh:RC254-282 03 medical and health sciences Sex Factors Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Serum Albumin Aged Proportional Hazards Models Retrospective Studies Lung Proportional hazards model business.industry association Clinical Cancer Research Retrospective cohort study Alkaline Phosphatase medicine.disease Confidence interval 030104 developmental biology business |
Zdroj: | Cancer Medicine Cancer Medicine, Vol 9, Iss 17, Pp 6268-6280 (2020) |
ISSN: | 2045-7634 |
Popis: | Objectives To investigate the relation between AAPR and OS in patients with advanced non‐small cell lung cancer (NSCLC). Methods A retrospective cohort study was conducted with 808 patients with advanced NSCLC who were treated in Guangxi Medical University Affiliated Tumor Hospital in China from 5 March 2009 to 31 August 2018. The target‐independent and dependent variables were AAPR measured in patients before anticancer treatment and overall survival (OS), respectively. Covariates involved in this study included age, gender, ECOG status, smoking history, clinical stages, pathological type, driver mutation (EGFR or ALK), metastasis or not (bone, lung, liver, brain, malignant plural effusion, and other organs), number of organ metastasis(≤3, >3), first‐line regiment and number of treatment lines (≤3, >3). Results The mean age of the selected patients was 58.3 ± 10.9 years and 68.6% were male. We divided patients according to their AAPR into low (AAPR 0.47, n = 283) tertile groups. Medium and high AAPR were associated with a decreased risk of death after fully adjusted Cox proportional hazard model(s) with hazards ratio (HR) 0.77 (95%CI = 0.58‐1.03) and HR 0.59 (95%CI = 0.45‐0.78), respectively (P for trend Using a retrospective cohort study with a large number of patients, this study investigates the relationships between albumin‐to‐alkaline phosphatase ratio as a prognostic factor for patients with advanced non‐small cell lung cancer. |
Databáze: | OpenAIRE |
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