Predictive value of pretreatment albumin‐to‐alkaline phosphatase ratio for overall survival for patients with advanced non‐small cell lung cancer

Autor: Shaozhang Zhou, Ni Wei, Qitao Yu, Huilin Wang, Wei Jiang
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Cancer Research
Lung Neoplasms
NSCLC
Gastroenterology
Metastasis
0302 clinical medicine
Carcinoma
Non-Small-Cell Lung
AAPR
subgroup analysis
Original Research
Hazard ratio
Age Factors
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Female
China
medicine.medical_specialty
overall survival
Subgroup analysis
lcsh:RC254-282
03 medical and health sciences
Sex Factors
Predictive Value of Tests
Internal medicine
Biomarkers
Tumor
medicine
Humans
Radiology
Nuclear Medicine and imaging
Lung cancer
Serum Albumin
Aged
Proportional Hazards Models
Retrospective Studies
Lung
Proportional hazards model
business.industry
association
Clinical Cancer Research
Retrospective cohort study
Alkaline Phosphatase
medicine.disease
Confidence interval
030104 developmental biology
business
Zdroj: Cancer Medicine
Cancer Medicine, Vol 9, Iss 17, Pp 6268-6280 (2020)
ISSN: 2045-7634
Popis: Objectives To investigate the relation between AAPR and OS in patients with advanced non‐small cell lung cancer (NSCLC). Methods A retrospective cohort study was conducted with 808 patients with advanced NSCLC who were treated in Guangxi Medical University Affiliated Tumor Hospital in China from 5 March 2009 to 31 August 2018. The target‐independent and dependent variables were AAPR measured in patients before anticancer treatment and overall survival (OS), respectively. Covariates involved in this study included age, gender, ECOG status, smoking history, clinical stages, pathological type, driver mutation (EGFR or ALK), metastasis or not (bone, lung, liver, brain, malignant plural effusion, and other organs), number of organ metastasis(≤3, >3), first‐line regiment and number of treatment lines (≤3, >3). Results The mean age of the selected patients was 58.3 ± 10.9 years and 68.6% were male. We divided patients according to their AAPR into low (AAPR 0.47, n = 283) tertile groups. Medium and high AAPR were associated with a decreased risk of death after fully adjusted Cox proportional hazard model(s) with hazards ratio (HR) 0.77 (95%CI = 0.58‐1.03) and HR 0.59 (95%CI = 0.45‐0.78), respectively (P for trend
Using a retrospective cohort study with a large number of patients, this study investigates the relationships between albumin‐to‐alkaline phosphatase ratio as a prognostic factor for patients with advanced non‐small cell lung cancer.
Databáze: OpenAIRE
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