Postoperative pain control in cats: clinical trials with pre-emptive lidocaine epidural co-administered with morphine or methadone
| Autor: | Natalia de Andrade Bicudo, Rafael DeRossi, Klebs Tavares de Assis, Paulo Henrique de Affonseca Jardim, Larissa Correa Hermeto |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Lidocaine 040301 veterinary sciences Ovariectomy Analgesic Injections Epidural Anesthesia General Hysterectomy Drug Administration Schedule 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Heart rate medicine Animals Anesthetics Local Small Animals Pain Measurement Pain Postoperative CATS Morphine business.industry 04 agricultural and veterinary sciences Pain scale Surgery Analgesics Opioid Treatment Outcome Anesthesia Anesthetic Cats Drug Therapy Combination Female business 030217 neurology & neurosurgery Methadone medicine.drug |
| Zdroj: | Journal of feline medicine and surgery. 18(11) |
| ISSN: | 1532-2750 |
| Popis: | Objectives The aim of the study was to evaluate the effectiveness of epidural lidocaine in combination with either methadone or morphine for postoperative analgesia in cats undergoing ovariohysterectomy. Methods Under general anesthesia, 24 cats that underwent ovariohysterectomy were randomly allocated into three treatment groups of eight each. Treatment 1 included 2% lidocaine (4.0 mg/kg); treatment 2 included lidocaine and methadone (4.0 mg/kg and 0.3 mg/kg, respectively); and treatment 3 included lidocaine and morphine (4.0 mg/kg and 0.1 mg/kg, respectively). All drugs were injected in a total volume of 0.25 ml/kg via the lumbosacral route in all cats. During the anesthetic and surgical periods, the physiologic variables (respiratory and heart rate, arterial blood pressure and rectal temperature) were measured at intervals of time zero, 10 mins, 20 mins, 30 mins, 60 mins and 120 mins. After cats had recovered from anesthesia, a multidimensional composite pain scale was used to assess postoperative analgesia 2, 4, 8, 12, 18 and 24 h after epidural. Results The time to first rescue analgesic was significantly ( P Conclusions and relevance The two combinations administered via epidural allowed ovariohysterectomy with sufficient analgesia in cats, and both induced prolonged postoperative analgesia. |
| Databáze: | OpenAIRE |
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