| Autor: |
Alyssa B Christensen, Brent Footer, Tobias Pusch, Kim Heath, Maha Iqbal, Lian Wang, Gregory Tallman, Cameron Cover, Jennifer Marfori, Brian Kendall, Nick Stucky, Meagan Greckel, Ivor L Thomas, Katelynn Tran, Salena Yip, Margret Oethinger |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Open Forum Infectious Diseases. 9 |
| ISSN: |
2328-8957 |
| Popis: |
Background Antimicrobial susceptibility testing (AST) is often needed prior to antimicrobial optimization for patients with gram-negative bloodstream infections (GN-BSIs). Rapid AST (rAST) in combination with antimicrobial stewardship (AS) may decrease time to administration of narrower antibiotics. Methods This was a prospective, nonblinded, randomized trial evaluating the impact of a phenotypic rAST method vs conventional AST (cAST) in hospitalized patients with GN-BSI and source control. The primary outcome was time to narrowest effective therapy. Results Two hundred seventy-four patients were randomized and 205 underwent analysis (97 cAST, 108 rAST). Median (interquartile range [IQR]) time to susceptibility results was 23 hours shorter in the rAST group (cAST: 62 [59–67] hours vs rAST: 39 [IQR, 35–46] hours; P Conclusions In patients with GN-BSI, rAST did not significantly decrease time to narrowest effective therapy but did decrease time to oral antibiotics and length of hospital stay. Rapid AST using existing microbiology platforms has potential to optimize patient outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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