Levels of prebeta-1 high-density lipoprotein are elevated in 3 phenotypes of dyslipidemia

Autor: Eveline O. Stock, Mary J. Malloy, Christine T. Ferrara, Josefina Naya-Vigne, John P. Kane, Clive R. Pullinger, Philip H. Frost, Patricia O’Connor
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Hyperlipidemias
030204 cardiovascular system & hematology
High-Density Lipoproteins
Pre-beta
Combined hyperlipidemia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Sex Factors
Internal medicine
Cholesterylester transfer protein
Hyperlipidemia
Internal Medicine
medicine
Humans
Triglycerides
Dyslipidemias
Hypertriglyceridemia
Nutrition and Dietetics
biology
Apolipoprotein A-I
Cholesterol
business.industry
Reverse cholesterol transport
Cholesterol
HDL
Age Factors
nutritional and metabolic diseases
Cholesterol
LDL
Middle Aged
medicine.disease
Up-Regulation
030104 developmental biology
Endocrinology
Phenotype
chemistry
Biochemistry
Case-Control Studies
biology.protein
Regression Analysis
lipids (amino acids
peptides
and proteins)
Female
Cardiology and Cardiovascular Medicine
business
Lipoprotein
Zdroj: Journal of clinical lipidology. 12(1)
ISSN: 1933-2874
Popis: Background Prebeta-1 high-density lipoprotein (HDL) is a small subspecies of HDL that functions as the HDL quantum particle and is the principal acceptor of cholesterol effluxed from macrophages through the ATP-binding cassette transporter, ABCA1. High levels of prebeta-1 HDL are associated with increased risk of structural coronary artery disease and myocardial infarction. Objective We aimed to compare prebeta-1 HDL levels in normal subjects and in 3 phenotypes of dyslipidemia. Methods We studied 2435 individuals (1388 women; 1047 men). Of these, 2018 were not taking lipid-lowering medication when enrolled: 392 were normolipidemic controls; 713 had elevated levels of low-density lipoprotein cholesterol; 623 had combined hyperlipidemia; and 290 had hypertriglyceridemia. Results Relative to controls, prebeta-1 HDL levels were increased in all 3 dyslipidemic phenotypes, particularly the combined and hypertriglyceridemia groups. This increase possibly reflects increased acceptor capacity of apolipoprotein B-100 containing lipoproteins for entropically driven transfer of cholesteryl esters from HDL via cholesteryl ester transfer protein. Multiple regression analysis revealed that the main predictor variables significantly associated with prebeta-1 HDL levels were apolipoprotein A-I (apoA-1) (β = 0.500), triglyceride (β = 0.285), HDL-C (β = −0.237), and age (β = −0.169). There was an interaction between apoA-1 and sex (female vs male; β = −0.110). Among postmenopausal women, estrogenized subjects had a similar level of prebeta-1 HDL compared to those not receiving estrogens. Conclusions Prebeta-1 HDL levels are elevated in the 3 most common types of hyperlipidemia and are most strongly influenced by the levels of apoA-1, triglyceride, and HDL-C.
Databáze: OpenAIRE
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