Dysregulation of complement factor H in juvenile-onset systemic lupus erythematosus patients
| Autor: | Eman Eissa, Botros Morcos, Dalia Dorgham, Naglaa Kholoussi |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Archives of Rheumatology. 37:417-423 |
| ISSN: | 2618-6500 2148-5046 |
| DOI: | 10.46497/archrheumatol.2022.9217 |
| Popis: | Objectives: This study aims to evaluate the expression pattern of factor H in peripheral blood and the frequency of factor H autoantibodies in plasma of juvenile-onset systemic lupus erythematosus (jSLE) patients compared to healthy controls. Patients and methods: Between March 2019 and October 2019, a total of 30 healthy individuals (3 males, 27 females; mean age: 26±7.4 years; range, 18 to 40 years) and 65 jSLE patients (age of onset ≤16 years) (2 males, 63 females; mean age: 23.4±7 years; range, 15 to 38 years) were included. Factor H expression pattern was examined in blood of all subjects using quantitative real-time polymerase chain reaction and the frequency of factor H autoantibodies was estimated in plasma using enzyme-linked immunosorbent assay. Results: Factor H expression was significantly downregulated in jSLE patients compared to healthy controls (p Conclusion: Our study results suggest that factor H expression can be dysregulated in jSLE patients. |
| Databáze: | OpenAIRE |
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