Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis
| Autor: | Rachael Pittaway, Lawrence Crossfield, Simon L. Priestnall, Ian Yl Yeung, Màrian Matas Riera, Rebekah Carling, Luca Fortuna, Oliver A. Garden, Charlotte Dawson, Yu-Mei Chang, Emma Scurrell, Caroline Thaung |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty T-Lymphocytes CD3 Disease Cat Diseases T-Lymphocytes Regulatory Feline Infectious Peritonitis 03 medical and health sciences 0302 clinical medicine Immune system Animals Medicine 030203 arthritis & rheumatology CATS General Veterinary biology business.industry FOXP3 Forkhead Transcription Factors medicine.disease Immunohistochemistry Uveitis Anterior Feline infectious peritonitis 030104 developmental biology Cats biology.protein business Uveitis |
| Zdroj: | VETERINARY OPHTHALMOLOGY |
| ISSN: | 1463-5216 |
| DOI: | 10.1111/vop.12569 |
| Popis: | To characterize the immune cells present in different forms of feline anterior uveitis.Eyes were obtained from 49 cats diagnosed with chronic idiopathic lymphoplasmacytic anterior uveitis, 7 cats with feline infectious peritonitis (FIP), and 9 cats euthanized for nonocular disease.HE sections were scored on the level of infiltrate in the anterior uvea. Immunohistochemistry was performed for FoxP3, CD3, and IL-17A, and positive cells were quantified in multiple images of each sample. A generalized estimating equation tested for an association between the level of inflammation and the prevalence of these cell types.Cells stained positive for IL-17A in idiopathic uveitis but not in FIP samples. We found significantly fewer FoxP3Idiopathic, but not FIP-associated, uveitis appears to have Th17 cell involvement. The numbers of FoxP3 |
| Databáze: | OpenAIRE |
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