Biomimetic total synthesis of (±)-garcibracteatone
| Autor: | Hiu C. Lam, Henry P. Pepper, Witold M. Bloch, Jonathan H. George |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Biomimetic materials Natural product Garcibracteatone Molecular Structure Chemistry Stereochemistry Organic Chemistry Phloroglucinol Total synthesis Electrophilic aromatic substitution Biochemistry chemistry.chemical_compound Biomimetic Materials Polycyclic Compounds Physical and Theoretical Chemistry |
| Zdroj: | Organic letters. 14(19) |
| ISSN: | 1523-7052 |
| Popis: | The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|