Multisite evaluations of a T 2 ‐relaxation‐under‐spin‐tagging ( TRUST ) MRI technique to measure brain oxygenation
| Autor: | Shaolin Yang, Trevor Andrews, Jacinda K. Dariotis, Peiying Liu, Ivan E. Dimitrov, Julie A. Dumas, Anand Kumar, Bradley J. Maclntosh, David E. Crane, Alan Tucholka, John E. Desmond, Guanghua Xiao, Hanzhang Lu, Guillaume Gilbert |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Canada medicine.medical_specialty Multivariate statistics Adolescent Spin tagging Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Negatively associated Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Oximetry Aged Aged 80 and over business.industry Healthy subjects Reproducibility of Results Venous oxygenation Oxygenation Middle Aged Image Enhancement Cerebral Veins Magnetic Resonance Imaging Healthy Volunteers United States Surgery Oxygen Standard error Cerebrovascular Circulation T2 relaxation Female Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | Magnetic Resonance in Medicine. 75:680-687 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.25627 |
| Popis: | Purpose Venous oxygenation (Yv) is an important index of brain physiology and may be indicative of brain diseases. A T2-relaxation-under-spin-tagging (TRUST) MRI technique was recently developed to measure Yv. A multisite evaluation of this technique would be an important step toward broader availability and potential clinical utilizations of Yv measures. Methods TRUST MRI was performed on a total of 250 healthy subjects, 125 from the developer's site and 25 each from five other sites. All sites were equipped with a 3 Tesla (T) MRI of the same vendor. The estimated Yv and the standard error (SE) of the estimation eYv were compared across sites. Results The averaged Yv and eYv across six sites were 61.1% ± 1.4% and 1.3% ± 0.2%, respectively. Multivariate regression analysis showed that the estimated Yv was dependent on age (P = 0.009) but not on performance site. In contrast, the SE of the Yv estimation was site-dependent (P = 0.024) but was less than 1.5%. Further analysis revealed that eYv was positively associated with the amount of subject motion (P |
| Databáze: | OpenAIRE |
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