Control of Francisella tularensis Virulence at Gene Level: Network of Transcription Factors
| Autor: | Pavla Stojkova, Petra Spidlova, Jiri Stulik, Anders Sjöstedt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Virulence Review Microbiology 03 medical and health sciences Transcription (biology) Virology Transcriptional regulation Francisella Gene Transcription factor lcsh:QH301-705.5 Francisella tularensis transcription factor 030304 developmental biology Genetics Regulation of gene expression 0303 health sciences biology 030306 microbiology pathogenesis Biochemistry and Molecular Biology biology.organism_classification virulence lcsh:Biology (General) gene regulation Biokemi och molekylärbiologi |
| Zdroj: | Microorganisms Microorganisms, Vol 8, Iss 1622, p 1622 (2020) |
| ISSN: | 2076-2607 |
| Popis: | Regulation of gene transcription is the initial step in the complex process that controls gene expression within bacteria. Transcriptional control involves the joint effort of RNA polymerases and numerous other regulatory factors. Whether global or local, positive or negative, regulators play an essential role in the bacterial cell. For instance, some regulators specifically modify the transcription of virulence genes, thereby being indispensable to pathogenic bacteria. Here, we provide a comprehensive overview of important transcription factors and DNA-binding proteins described for the virulent bacterium Francisella tularensis, the causative agent of tularemia. This is an unexplored research area, and the poorly described networks of transcription factors merit additional experimental studies to help elucidate the molecular mechanisms of pathogenesis in this bacterium, and how they contribute to disease. |
| Databáze: | OpenAIRE |
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