Validation of the Children's International Mucositis Evaluation Scale (ChIMES) in paediatric cancer and SCT
| Autor: | P. Judd, R. Agarwal, Tal Schechter, Shana Jacobs, Joseph Beyene, Christina Baggott, Deborah Tomlinson, Lillian Sung, T. Hesser |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Mucositis Cancer Research Pediatrics medicine.medical_specialty Transplantation Conditioning Adolescent MEDLINE Severity of Illness Index 03 medical and health sciences 0302 clinical medicine children Neoplasms Surveys and Questionnaires Severity of illness Medicine Humans 030212 general & internal medicine Prospective cohort study Child Stomatitis business.industry Mouth Mucosa Construct validity Myeloablative Agonists medicine.disease Combined Modality Therapy 3. Good health Surgery Clinical trial Transplantation Oncology 030220 oncology & carcinogenesis Scale (social sciences) hematopoietic stem cell transplantation Clinical Study Female business Stem Cell Transplantation |
| Zdroj: | British Journal of Cancer Baggott, Christina; Jacobs, S; Agarwal, R; Hesser, T; Schechter, T; Judd, P; et al.(2013). Validation of the Children's International Mucositis Evaluation Scale (ChIMES) in paediatric cancer and SCT.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4gc5f9dv |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Objectives were to describe the reliability and validity of a new paediatric-specific mucositis scale, the Children's International Mucositis Evaluation Scale (ChIMES). Methods: In a multi-centre prospective study, children aged 0 to ⩽18 years were eligible if they were receiving any of the following: myeloablative stem cell transplantation (SCT), ⩾60 mg m−2 course−1 doxorubicin or ⩾12 g m−2 methotrexate. Multiple measures of mucositis were included along with ChIMES. Respondents were parent proxy report for children aged 0.8 for all respondent types. Criteria for construct validation were met across all measures. ChIMES also demonstrated responsiveness with significant differences between baseline and Day 14. Conclusion: ChIMES is a paediatric-specific measure of mucositis with favourable psychometric properties. It exhibits reliability, construct validity and responsiveness. ChIMES should be incorporated into clinical trials of mucositis prevention and treatment in paediatric cancer and SCT. |
| Databáze: | OpenAIRE |
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