Effect of Tetrahydropyranyladriamycin(THP-ADR) and 4'-Epiadriamycin(4'-Epi-ADR) on Lipid Peroxide Levels in Mice
| Autor: | Yasuyuki Sadzuka, Yoshio Takino |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Lipid Peroxides medicine.medical_specialty Mice Inbred Strains GPX4 Lipid peroxidation Mice chemistry.chemical_compound In vivo Internal medicine Drug Discovery medicine Animals Epirubicin chemistry.chemical_classification biology Lipid peroxide Chemistry Glutathione peroxidase General Chemistry General Medicine Glutathione Glutathione S-transferase Endocrinology Doxorubicin biology.protein Microsome lipids (amino acids peptides and proteins) |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 40:1329-1331 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.40.1329 |
| Popis: | Lipid peroxide levels were measured in mouse tissues to study their relation to the cardiotoxicity of anthracyclines. The effects of tetrahydropyranyladriamycin (THP-ADR) and 4'-epiadriamycin (4'-epi-ADR), which are less cardiotoxic than adriamycin (ADR), were examined. Neither THP-ADR nor 4'-epi-ADR increased the lipid peroxide levels in the heart, however, both increased reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent lipid peroxidation in mouse liver and lung microsomes, to the same degree as ADR. Therefore, the results obtained in vitro were not the same as those obtained in vivo. Of all of the anthracyclines tested, only THP-ADR increased the lipid peroxide levels in the lung. Thus, THP-ADR may be pulmotoxic. Differences in the activities of glutathione peroxidase and glutathione S-transferase reflected the differences in lipid peroxide levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|