Increased plasma hyaluronan in severe pre-eclampsia and eclampsia
| Autor: | Sören Berg, A Engman, T. C. Laurent, T Lundahl, Susanna Holmgren |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Cirrhosis medicine.medical_treatment Clinical Biochemistry Preeclampsia chemistry.chemical_compound Pre-Eclampsia Pregnancy Internal medicine Hyaluronic acid Blood plasma medicine Humans Eclampsia Caesarean section Aspartate Aminotransferases Hyaluronic Acid reproductive and urinary physiology Platelet Count business.industry Vaginal delivery General Medicine medicine.disease female genital diseases and pregnancy complications Endocrinology chemistry Case-Control Studies Creatinine Female Liver function business |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 61:131-137 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365510151097647 |
| Popis: | Pre-eclampsia is a serious multi-system disorder with general endothelial disease, often with a component of hepatic dysfunction. The pathogenesis of preeclampsia is not fully understood, and no specific diagnostic tests are available for early and reliable diagnosis, or for monitoring of the disease process. Hyaluronan is an extracellular matrix polysaccharide present at low concentrations in plasma. Normally, it is rapidly eliminated from the blood by the liver. Increased concentrations of circulating hyaluronan are seen in conditions with impaired hepatic function such as liver cirrhosis, and hyaluronan concentrations have previously been used to evaluate hepatic function in other diseases. In the present study, 11 pregnant women admitted to the intensive care unit with severe pre-eclampsia or eclampsia were studied. As control 31 healthy pregnant women, 18 undergoing vaginal delivery and 13 caesarean section, were included. Plasma hyaluronan was measured before and after delivery. Increased concentrations of plasma hyaluronan were found in the pre-eclampsia group both before (171 (75-586) microg/L (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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