Expression of nerve growth factor-like polypeptides and immunoreactivity related to the two types of neurotrophin receptors in earthworm tissues
| Autor: | Annalucia Serafino, A. Marconi, C. Davoli, Giampietro Ravagnan, Adriana Marcheggiano, C. Iannoni |
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| Rok vydání: | 2002 |
| Předmět: |
Central Nervous System
Nervous system Blotting Western Receptors Nerve Growth Factor Receptor tyrosine kinase Cellular and Molecular Neuroscience evolution Nerve Growth Factor medicine Animals Low-affinity nerve growth factor receptor Oligochaeta Receptor Molecular Biology Caenorhabditis elegans Pharmacology Microscopy Confocal biology neurotrophin p75 receptor Cell Biology Anatomy biology.organism_classification Immunohistochemistry Cell biology Microscopy Electron Nerve growth factor medicine.anatomical_structure nervous system Organ Specificity Trk receptor biology.protein Molecular Medicine Peptides Neurotrophin |
| Zdroj: | Cellular and molecular life sciences (Print. ed.) 59 (2002): 527–539. info:cnr-pdr/source/autori:Davoli C. 1, Marconi A. 2, Serafino A. 3, Iannoni C. 4, Marcheggiano A. 5, Ravagnan G. 6/titolo:Expression of nerve growth factor-like polypeptides and immunoreactivity related to the two types of neurotrophin receptors in earthworm tissues/doi:/rivista:Cellular and molecular life sciences (Print. ed.)/anno:2002/pagina_da:527/pagina_a:539/intervallo_pagine:527–539/volume:59 |
| ISSN: | 1420-9071 1420-682X |
| DOI: | 10.1007/s00018-002-8444-4 |
| Popis: | Nerve growth factor (NGF) belongs by sequence homology to the neurotrophins, a family of proteins binding the same p75 receptor and closely related members of the Trk family of receptor tyrosine kinases. Fundamental in the vertebrate nervous system, neurotrophin signals have also been suggested as essential for relatively complex nervous systems occurring in invertebrate species that live longer than Caenorhabditis elegans and Drosophila melanogaster. Mammalian neurotrophins have been found to influence invertebrate neuronal growth. However, there are only a few data on the presence of molecules related to neurotrophin signalling components in invertebrates. Our studies provide evidence that analogues of neurotrophins and neurotrophin receptors are expressed in Eisenia foetida earthworms. In particular, NGF-like and Trk-like immunoreactive proteins are both expressed in the nervous system, whereas p75-like positivity identifies tubular structures associated with dorsal pores that are involved in the earthworm response to mechanical irritation or stress. |
| Databáze: | OpenAIRE |
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