Transfer of chromic chloride to embryonic mice and changes in the embryonic mouse neuroepithelium
| Autor: | Sumio Iijima, Chiung-chen Lu, Nobuo Matsumoto |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Chromium
medicine.medical_treatment Intraperitoneal injection Gestational Age Exencephaly Biology Toxicology Epithelium Andrology Mice Chlorides Pregnancy Chromium Compounds medicine Animals Neural Tube Defects Maternal-Fetal Exchange Mice Inbred ICR Neural tube Embryo Anatomy medicine.disease Neuroepithelial cell medicine.anatomical_structure Gestation Female Neural plate Pyknosis |
| Zdroj: | Toxicology. 26:257-265 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(83)90086-0 |
| Popis: | Transfer of CrCl3 to embryonic mice and changes in the embryonic mouse neuroepithelium associated with Cr-induced neural tube defects were studied. A single intraperitoneal injection of 51CrCl3 was administered on the 8th day of gestation and animals were killed at various intervals for measurements of radioactivity in the maternal blood and embryos. Radioactivity per gram of fetal tissues increased during the observed period, while those of maternal blood decreased. Pregnant mice were injected intraperitoneally with a single dose of CrCl3 (non-radioactive) on the 8th day of gestation. Animals were killed at specified times after injection and embryos were removed and examined histologically. At 4, 8 and 12 h after injection many pyknotic cells were observed on the neural plate, especially at 8 h after injection. These data suggest that CrCl3 may affect embryos directly and cause neural tube defects and that pyknotic cells on the neural plate may be an early pathological finding in cases of developing exencephaly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|