Non-surgical periodontal therapy with adjunctive topical doxycycline: a double-masked, randomized, controlled multicenter study. II. Microbiological results
| Autor: | Boris Böddinghaus, Peter Eickholz, Ti-Sun Kim, H. H. Renggli, Petra Ratka-Krüger, Beate Schacher, Rolf Holle, Thomas Bürklin |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Administration Topical Dental Plaque Dentistry Drug resistance Gastroenterology Root Planing Scaling and root planing Double-Blind Method Clavulanic acid Internal medicine Drug Resistance Bacterial medicine Humans Periodontal Diseases Aged Doxycycline Periodontitis business.industry Clindamycin Amoxicillin Middle Aged medicine.disease Anti-Bacterial Agents Metronidazole Periodontics Dental Scaling Female business Gels medicine.drug |
| Zdroj: | Journal of periodontology. 76(1) |
| ISSN: | 0022-3492 |
| Popis: | Background: Topical application of active substances offers an additional option in periodontal therapy. The aim of this study was to examine the influence of the administration of a novel, biodegradable 14% doxycycline gel on microbiological findings, in connection with scaling and root planing. Methods: One hundred ten patients in three centers (Frankfurt and Heidelberg, Germany; Nijmegen, The Netherlands) with moderate to advanced periodontitis were evaluated in this randomized, double-masked, split-mouth clinical trial. In each patient, three test teeth were randomly assigned to one of three treatment modalities: 1) scaling and root planing (SRP) alone; 2) SRP with subgingival placebo gel (VEH); or 3) SRP and 14% doxycycline gel (DOX). Subgingival plaque samples were analyzed at baseline and 3 and 6 months after therapy for Actinobacillus actinomycetemcomitans (A.a.), Tannerella forsythensis (T.f.), Porphyromonas gingivalis (P.g.), and Treponema denticola (T.d.) using a RNA probe. Samples from 10 patients were tested for resistance against doxycycline, amoxicillin/clavulanic acid, cefoxitin, clindamycin, and metronidazole using agar diffusion testing. Results: The largest decrease in pathogens was found after 3 months, with the most pronounced differences between DOX and SRP (P |
| Databáze: | OpenAIRE |
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