Obstructive sleep apnea is independently associated with subclinical coronary atherosclerosis among middle-aged women
| Autor: | Luciano F. Drager, Martinha M.B. Carvalho, Ricardo Quental Coutinho, Márcio Sommer Bittencourt, Ana Kelley de Lima Medeiros, Isly Maria Lucena de Barros, Rodrigo P. Pedrosa, Moacir de Novaes Lima Ferreira, Maria Priscila Figueiredo Lira, Ana Paula Dornelas Leão Leite, Geraldo Lorenzi-Filho, Thais C. Lustosa, Laura Olinda Bregieiro Fernandes Costa |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Statistics as Topic Coronary Artery Disease 030204 cardiovascular system & hematology Selenic Acid Cohort Studies 03 medical and health sciences 0302 clinical medicine Sex Factors Risk Factors Internal medicine medicine Humans Sleep study Vascular Calcification Coronary atherosclerosis Subclinical infection Sleep Apnea Obstructive Framingham Risk Score business.industry Middle Aged Overweight medicine.disease respiratory tract diseases Coronary Calcium Score Obstructive sleep apnea 030228 respiratory system Otorhinolaryngology Heart failure Cardiology Female Neurology (clinical) business Body mass index |
| Zdroj: | Sleepbreathing = SchlafAtmung. 21(1) |
| ISSN: | 1522-1709 |
| Popis: | Obstructive sleep apnea (OSA) is associated with coronary disease among men. However, this association is not clear for women. In this study, we evaluate the association between OSA and presence of subclinical atherosclerosis assessed by tomographic coronary calcium score in middle-aged women. We evaluated consecutive women aged between 45 and 65 years in perimenopause or postmenopause period (with menstrual irregularity—amenorrhea > 60 days), without manifest cardiovascular disease (heart failure, coronary disease, and stroke), from two gynecologic clinics. All patients underwent clinical evaluation, computed tomographic examination for coronary artery calcium (CAC > 100 Agatston units), and portable sleep study. Multiple logistic regression models were used to evaluate the association between OSA and CAC, controlling for traditional risk factors including Framingham Risk Score (FRS), body mass index (BMI), and diabetes. We studied 214 women (age 56 years (52–61); BMI 28 kg/m2 (25–31), 25 % diabetes, 62 % hypertension). OSA (apnea-hypopnea index (AHI) ≥5 events/h) was diagnosed in 82 women (38.3 %). CAC was more prevalent in patients with moderate/severe OSA (AHI ≥15 events/h) than in patients without or with mild OSA, 19 % vs 4.5 and 1.6 %, respectively (p |
| Databáze: | OpenAIRE |
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