Hepatitis B in Household Contacts of Children with Beta-Thalassemia
| Autor: | Dimitris A. Papanastasiou, Iris Th. Spiliopoulou, Ourania G. Papageorgiou, Nicholas G. Beratis |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Viral Hepatitis Vaccines Adolescent medicine.disease_cause Serology Seroepidemiologic Studies Prevalence medicine Humans Hepatitis B e Antigens Hepatitis B Antibodies Child Hepatitis B virus Hepatitis B Surface Antigens Greece business.industry Beta thalassemia Viral hepatitis b Hematology General Medicine Middle Aged Hepatitis B medicine.disease Hepatitis B Core Antigens Virology Hemoglobinopathy Child Preschool Immunology Thalassemia Female Viral disease business Biomarkers |
| Zdroj: | Acta Haematologica. 84:182-185 |
| ISSN: | 1421-9662 0001-5792 |
| Popis: | The hepatitis B virus (HBV) markers have been studied in 184 household contacts of 110 thalassemic patients and 184 normal individuals matched for age and socioeconomic status with the study subjects. The mean age (+/- SD) in both patients and control subjects was 31.1 +/- 13.5 years. HBV infection had occurred in 51.6% of the household contacts and in 32.1% of the control subjects. This difference is highly significant (p less than 0.001). The most frequent marker observed was the antihepatitis B core IgG followed by the antihepatitis B surface antibody. It is noteworthy that none of the thalassemic patients infected in the past was seropositive for the hepatitis B surface antigen at the time of the study, whereas its frequency in the general population was 8.1%. The findings indicate that the household contacts of thalassemic patients have a greater seroprevalence for hepatitis B infection. Furthermore, the household contacts of thalassemic patients are infected at a younger age than the control population. The high infection rate with HBV in all groups tested suggests that vaccination should be considered not only for the household contacts of thalassemic patients but possibly for the entire Greek population. |
| Databáze: | OpenAIRE |
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