Cancer patients’ acceptability of incorporating an epidemiology questionnaire within a clinical trial
| Autor: | Alexander Montenegro, Henrique Hon, John Waldron, Christine E. Simmons, Wendy R. Parulekar, Wei Xu, Osvaldo Espin-Garcia, Kimberly Tobros, Bingshu E. Chen, Luke Harland, Ehab Fadhel, Geoffrey Liu, Yonathan Brhane, Anthony LaDelfa, Lillian L. Siu, Lawson Eng, Zahra Kassam, Sinead Cuffe |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Research Subjects Context (language use) Disease Young Adult Neoplasms Surveys and Questionnaires Epidemiology medicine Humans In patient Aged Randomized Controlled Trials as Topic Aged 80 and over Ontario Pharmacology Epidemiological Factors business.industry Head and neck cancer Cancer General Medicine Middle Aged medicine.disease Clinical trial Clinical Trials Phase III as Topic Socioeconomic Factors Research Design Physical therapy Female business |
| Zdroj: | Clinical Trials. 12:237-245 |
| ISSN: | 1740-7753 1740-7745 |
| DOI: | 10.1177/1740774514568689 |
| Popis: | Background/aims Understanding the influence or impact of epidemiological factors on cancer outcomes in clinical trials can broaden our knowledge of disease, trial populations and therapeutic effects thus leading to improved patient care. However, there is a lack of data on cancer patients’ compliance with an epidemiology questionnaire in the context of a clinical trial. Patients and methods Cancer patients were provided with a hypothetical scenario and surveyed regarding their willingness and preferences to complete an epidemiology questionnaire if incorporated into a cancer therapy trial. Patient compliance with completing a voluntary epidemiology questionnaire and trial coordinators perceptions therein were separately determined in the NCIC Clinical Trials Group HN.6 clinical trial, an ongoing randomized phase III trial comparing two first-line treatment regimens in patients with locoregionally advanced head and neck cancer. Results Of 617 cancer patients from community, academic and tertiary cancer centres, the majority were willing to complete an epidemiology questionnaire either unconditionally (45%), or provided it did not inconvenience them (31%); 4% would refuse. Patients preferred shorter questionnaires of 30–50 questions requiring 10–20 min to complete, administered over 1–3 sessions. Patients were less willing, but still compliant, to answer questions relating to sexual history (71%) and annual household income (66%) relative to other questions (>90%). Eighteen percent thought that the questionnaire should be mandatory, with 31% believing that they may benefit personally from such research. In the HN.6 trial, compliance averaged 94.8% per question. Conclusions Cancer patients are very willing to complete epidemiology questions in clinical trials. |
| Databáze: | OpenAIRE |
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