Seroprevalence of seven high-risk HPV types in The Netherlands
| Autor: | Guy A. M. Berbers, Rutger M. Schepp, Hester E. de Melker, Hein J. Boot, Fiona R. M. van der Klis, Madelief Mollers, Chris J.L.M. Meijer, Mirte Scherpenisse |
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| Přispěvatelé: | Pathology, CCA - Oncogenesis |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Serotype Adolescent Cross-sectional study Population Antibodies Viral Young Adult Risk Factors Seroepidemiologic Studies Humans Medicine Seroprevalence Papillomavirus Vaccines Serotyping Young adult Seroconversion Child education Papillomaviridae Aged Netherlands education.field_of_study General Veterinary General Immunology and Microbiology business.industry Papillomavirus Infections Public Health Environmental and Occupational Health Infant Middle Aged Vaccination Cross-Sectional Studies Infectious Diseases Child Preschool Immunology Molecular Medicine Female business Demography |
| Zdroj: | Vaccine, 30(47), 6686-6693. Elsevier BV Scherpenisse, M, Mollers, M, Schepp, R M, Boot, H J, de Melker, H E, Meijer, C J L M, Berbers, G A M & van der Klis, F R M 2012, ' Seroprevalence of seven high-risk HPV types in The Netherlands ', Vaccine, vol. 30, no. 47, pp. 6686-6693 . https://doi.org/10.1016/j.vaccine.2012.08.068 |
| ISSN: | 0264-410X |
| Popis: | Background To obtain insight into the age-specific seroprevalence for seven high-risk human papillomavirus (hr-HPV) serotypes (HPV16, 18, 31, 33, 45, 52, and 58) among the general population in the pre-vaccination era in The Netherlands. Methods From a cross-sectional population-based study (ISRCTN 20164309) performed in 2006/2007 6384 sera of men, women and children were tested for seven hr-HPV specific antibodies using a fluorescent bead-based multiplex immunoassay with virus-like particles of the seven HPV serotypes. Results An increase in seroprevalence was observed in adolescents, especially for the most prevalent HPV type 16 (up to 11.3%). The increase was most pronounced in women, but was less clear for the other six HPV serotypes. Relatively stable seroprevalences were found in the middle aged cohorts and a slight decrease in the elderly. For the age cohorts >14 years, the seroprevalence among women (25.2%) was higher compared with men (20.3%) (p = 0.0002). We found that 10.1% of the population was seropositive for multiple HPV serotypes. Conclusions The HPV vaccination program is targeted at preadolescents as is justified by the results in this study in which a step-up in HPV seroprevalence is observed at ages of sexual debut. Although direct interpretation of seroprevalence data are hampered by cross-reactivity and seroconversion rate, these data are useful as baseline to evaluate long-term population effects of the HPV16/18 vaccination program. |
| Databáze: | OpenAIRE |
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