Attenuation of contrast material-induced renal artery vasoconstriction by nitric oxide donors
| Autor: | Paul O. Madsen, Peter Drescher |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Nitroprusside
Molsidomine Endothelium Vasodilator Agents Iomeprol Contrast Media Pharmacology Nitric Oxide Muscle Smooth Vascular Iopamidol Nephrotoxicity Phenylephrine chemistry.chemical_compound Renal Artery medicine.artery medicine Animals Humans Vasoconstrictor Agents Radiology Nuclear Medicine and imaging Enzyme Inhibitors Renal artery Dose-Response Relationship Drug business.industry Endothelins Iodixanol Tissue Donors NG-Nitroarginine Methyl Ester medicine.anatomical_structure chemistry Vasoconstriction Anesthesia Endothelium Vascular Rabbits medicine.symptom business Muscle Contraction medicine.drug |
| Zdroj: | Academic Radiology. 4:788-794 |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/s1076-6332(97)80254-1 |
| Popis: | Rationale and Objectives. The authors studied the role of the endothelium and associated endothelial pathways in contrast material—induced renal vasoconstriction. Materials and Methods. Isometric contractions in human and rabbit renal artery rings with intact and denuded endothelium were stimulated with phenylephrine and increasing concentrations of the ionic contrast material diatrizoate, the nonionic contrast materials iopamidol and iomeprol, and the dimetric contrast material iodixanol in a tissue perfusion bath. Rings with intact endothelium were incubated with endothelium-stimulating compounds such as the NO synthetase inhibitor N g nitro- l -arginine methyl ester ( l -NAME) to study the endothelium-mediated vasomotor regulation and the NO-liberating substances molsidomine (SIN-1) and nitroprusside (NPR) to study the endothelial-mediated vasorelaxation before being stimulated with contrast material. Results. Contrast material—induced, dose-dependent, reversible renal artery contractions are dependent on the type of contrast material. No differences in the contractions were found between intact and denuded rings. l -NAME had no effect on contrast material—induced contractions. Contractions were inhibited by the NO donors SIN-1 and NPR. SIN-1 was the most potent inhibitor. Conclusion. Contrast material—induced renal vasoconstriction is endothelium-independent. Selective pharmacologic stimulation of the endothelium by NO donors, however, may still be useful in the prophylaxis of contrast material—induced renal vasoconstriction and, thus, potentially nephrotoxicity. |
| Databáze: | OpenAIRE |
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