Cushing’s syndrome: comparison between Cushing’s disease and adrenal Cushing’s
| Autor: | Sandra Alboim, Vered Kopel, Varda Nadler, Ilan Shimon, Gloria Tsvetov, Nirit Aviran-Barak, Yossi Manisterski, Dania Hirsch, Oren Amitai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Younger age Hydrocortisone Endocrinology Diabetes and Metabolism Adrenal Gland Neoplasms 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Pituitary adenoma Internal medicine Diabetes mellitus medicine Humans Pituitary ACTH Hypersecretion Cushing Syndrome Aged Retrospective Studies S syndrome business.industry Cushing's disease Middle Aged medicine.disease ACTH-Secreting Pituitary Adenoma 030220 oncology & carcinogenesis Lower prevalence Etiology Female business Glucocorticoid medicine.drug |
| Zdroj: | Endocrine. 62:712-720 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-018-1709-y |
| Popis: | The most common etiology of Cushing’s syndrome (CS) is an ACTH-producing pituitary adenoma (pitCS), reported as 2–3 times more frequent than primary adrenal CS (adrCS). We aimed to analyze and compare features of patients with pitCS and adrCS. A retrospective file review of 196 consecutive patients (age 46.8 ± 15.6 years, 76% female) diagnosed with CS in 2000–2017 and followed for 5.2 ± 4.2 years; 109 (55.6%) had pitCS and 76 (38.8%) adrCS. Epidemiologic, clinical and biochemical factors were compared between and within the pitCS and adrCS groups. The relative proportion of pitCS to adrCS (1.4) was lower than previously reported and gradually decreased during the study years to only 1.2 in 2012–2017. The most common reason for CS screening was weight-gain in the pitCS group (48.6%) and adrenal incidentaloma in the adrCS group (39.5%). The pitCS patients were diagnosed at younger age (42.5 ± 15.1 vs. 51.6 ± 15.1 years, p |
| Databáze: | OpenAIRE |
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