Elevated testosterone on immunoassay in a patient with metastatic prostate cancer following androgen deprivation therapy and bilateral orchiectomy
| Autor: | Richard J. Fantus, Joshua A. Halpern, Arjun Sarkar, Ashley E. Ross, Mohammad Rashid Siddiqui, Maha Hussain |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Heterophile Urology 030232 urology & nephrology Androgen deprivation therapy 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Heterophile antibody Medicine biology medicine.diagnostic_test Mass spectrometry business.industry Testosterone (patch) medicine.disease Diseases of the genitourinary system. Urology Castration Testosterone assay chemistry Oncology 030220 oncology & carcinogenesis Immunoassay biology.protein Elevated testosterone RC870-923 Antibody business |
| Zdroj: | Urology Case Reports Urology Case Reports, Vol 38, Iss, Pp 101657-(2021) |
| ISSN: | 2214-4420 |
| Popis: | We present the case of an 83-year-old man with metastatic prostate cancer who had testosterone levels reading above castration range despite appropriate medical and surgical castration. Mass spectrometry was performed to confirm presence of testosterone, but no testosterone was detected. The elevated testosterone as measured by standard immunoassay was postulated to be secondary to heterophile antibodies in the patient's serum. This report highlights the need for a high index of suspicion for interference in testosterone immunoassays when levels remain mildly elevated. Mass spectrometry may provide a more reliable method by which to detect testosterone concentration prior to escalation of care. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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