Effect of hydrophilic and lipophilic vehicles on skin permeation of tegafur, alclofenac and ibuprofen with or without permeation enhancers
| Autor: | Nak-Seo Kim, Takahiro Uchida, Shigeru Goto, Kazuhisa Kitagawa, Cheon Koo Lee, Akira Yagi |
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| Rok vydání: | 1993 |
| Předmět: |
Skin Absorption
Pharmaceutical Science Excipient Ibuprofen Absorption (skin) Tegafur chemistry.chemical_compound Mice medicine Animals Rats Wistar Phenylacetates Pharmacology Mice Hairless Chromatography Ethanol Chemistry General Medicine Permeation Alclofenac Rats Lipophilicity Female Pharmaceutical Vehicles medicine.drug |
| Zdroj: | Biologicalpharmaceutical bulletin. 16(12) |
| ISSN: | 0918-6158 |
| Popis: | The effects of an ethanol/panasate 800 (tricaprylin) (40/60) system as a lipophilic vehicle, and an ethanol/water (60/40) system as a hydrophilic vehicle, with or without permeation enhancers for in vitro skin permeation and in vivo skin absorption of tegafur, alclofenac and ibuprofen with different lipophilicity, were evaluated.The in vitro and in vivo skin permeability of tegafur, alclofenac and ibuprofen was enhanced by the use of ethanol/panasate 800 (40/60) or ethanol/water (60/40) binary vehicles as a donor composition. However, the two vehicles showed contrastive properties in relation to the extent of permeation enhancement of the three drugs : tegafur > alclofenac > ibuprofen for the ethanol/panasate 800 (40/60) system, and ibuprofen ≥ alclofenac > tegafur for the ethanol/water (60/40) system. When lauric acid, as a permeation enhancer, was added to both of the binary vehicles, the in vitro and in vivo skin permeability of three drugs further increased, and the in vivo absorption rate of the drugs from the ethanol/water (60/40) system was larger than that from the ethanol/panasate 800 (40/60) system. In conclusion, it was suggested that the ethanol/panasate 800 (40/60) lipophilic binary vehicle is useful for hydrophilic drugs, and conversely, the skin absorption of lipophilic drugs can be improved by the use of the ethanol/water (60/40) hydrophilic binary vehicle with or without lauric acid as a permeation enhancer. |
| Databáze: | OpenAIRE |
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