Controlled attenuation parameter measured using transient elastography for the noninvasive assessment of macrovesicular steatosis in potential living liver donors
| Autor: | Lee, Sunyoung, Kim, Kyoung Won, Kim, So Yeon, Seo, Nieun, Song, Gi-Won, Lee, Sung-Gyu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
musculoskeletal diseases
Youden's J statistic living donors Biopsy medicine Medical technology Radiology Nuclear Medicine and imaging R855-855.5 liver biopsy Receiver operating characteristic medicine.diagnostic_test business.industry Attenuation fungi Macrovesicular steatosis transient elastography Confidence interval controlled attenuation parameter body regions Liver biopsy macrovesicular steatosis Original Article lipids (amino acids peptides and proteins) Transient elastography business Nuclear medicine hormones hormone substitutes and hormone antagonists |
| Zdroj: | Ultrasonography, Vol 41, Iss 1, Pp 164-170 (2022) Ultrasonography |
| ISSN: | 2288-5943 2288-5919 |
| Popis: | Purpose: This study aimed to determine the diagnostic performance of the controlled attenuation parameter (CAP) measured using transient elastography (TE) for assessing macrovesicular steatosis (MaS) in potential living liver donors using same-day biopsy as a reference standard.Methods: This retrospective study included 204 living liver donor candidates who underwent TE and liver biopsy on the same day between July 2013 and June 2014. The histologic degree of MaS was determined. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the performance of CAP for diagnosing MaS of >10%, and the optimal cutoff value was identified using the maximal Youden index.Results: Based on liver biopsy, 185 subjects had MaS of ≤10% and 19 had MaS of >10%. The CAP value was significantly correlated with the percentage of MaS on liver biopsy (r=0.635, P10% than in those with MaS of ≤10% (300 dB/m vs. 209 dB/m, P10% by CAP was 0.938 (95% confidence interval, 0.896 to 0.967), and a CAP of >259 dB/m yielded a sensitivity of 84.2% and a specificity of 92.4%.Conclusion: The CAP measured using TE was significantly correlated with MaS and accurately detected substantial MaS in potential living liver donors. The CAP is a promising tool for the noninvasive diagnosis of MaS and may be used to screen unsuitable living liver donor candidates. |
| Databáze: | OpenAIRE |
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