Biochanin-A elicits relaxation in coronary artery of goat through different mechanisms
| Autor: | Madhu Cholenahalli Lingaraju, Tarun Kumar, Subhashree Parida, Dinesh Kumar, M. C. Sharma, Thakur Uttam Singh, Abhinav Rana |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Endothelium 040301 veterinary sciences Vasodilator Agents Flavonoid Pharmacology Biochanin A 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Bkca channel medicine Animals Beneficial effects 030304 developmental biology chemistry.chemical_classification 0303 health sciences General Veterinary Relaxation (psychology) Chemistry Goats 04 agricultural and veterinary sciences Coronary Vessels Genistein Vasodilation medicine.anatomical_structure Mechanism of action Endothelium Vascular medicine.symptom Artery |
| Zdroj: | Research in veterinary science. 131 |
| ISSN: | 1532-2661 |
| Popis: | Flavonoids have shown beneficial effects in various disease conditions as reported by various previous studies. Biochanin-A is a flavonoid present in various plants in nature. Present investigation was done to assess the vasorelaxant potential of biochanin-A on isolated coronary artery of goat and its possible mechanism of action. Vascular reactivity experiments were done on circumflex coronary artery of goats using the tension experiments. Goat coronary arterial rings were relaxed with biochanin-A in concentration (0.1–100 μM)-dependent manner. Endothelium had no effect on biochanin-A-induced relaxation. Maximum relaxation induced by biochanin-A was 116.54 ± 12.21% in endothelium-intact artery and it was not significantly different with maximal relaxation (108.22 ± 1.88%) of endothelium-denuded vessel. L-NAME (100 μM) did not show any effect on biochanin-A-induced relaxation. TEA (BKCa channel blocker), and BaCl2 (KIR blocker) had no effect on biochanin-A-induced relaxation. However, biochanin-A-induced maximal relaxation (71.72 ± 4.50%) was reduced significantly (P |
| Databáze: | OpenAIRE |
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