Anti-oxidative effect of resveratrol on aluminum induced toxicity in rat cerebral tissue
| Autor: | M. M. H. Zakaria, Babak Hajipour, B. M. Saleh, Rasoul Estakhri |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Economics and Econometrics Antioxidant medicine.medical_treatment 010501 environmental sciences Pharmacology Resveratrol medicine.disease_cause 01 natural sciences Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Stilbenes Materials Chemistry Media Technology medicine Animals Rats Wistar Aluminum Compounds 0105 earth and related environmental sciences chemistry.chemical_classification Brain Forestry Rats Oxidative Stress 030104 developmental biology Enzyme Neuroprotective Agents chemistry Toxicity Nerve Degeneration Anti oxidative Cerebral tissue Lipid Peroxidation Neuroglia Oxidative stress |
| Zdroj: | Bratislavske lekarske listy. 118(5) |
| ISSN: | 0006-9248 |
| Popis: | View references (35) INTRODUCTION: The direct protective effects of resveratrol against oxidative stress have been demonstrated in neuroglial cells, the mechanisms of these effects are not fully understood. The aim of this research was to study the effect of resveratrol on AL induced cerebral injury in rat. METHODS: We divided the groups as follows with 10 animals each: a) Group I - served as control receiving normal drinking water and diet ad libitum. b) Group II - animals were administered aluminum at a dose level of 100 mg/kg body weight for a period of 6 weeks daily through oral gavage. c) Group III - animals were administered aluminum at a dose level of 100 mg/kg body weight and resveratrol at a dose of 10 mg/kg body weight intraperitoneally for a period of 6 weeks daily. After 6 weeks rats were anesthetized and decapitated. Brains were removed immediately and frozen in liquid nitrogen RESULTS: The levels of SOD and GPx antioxidant enzymes were decreased in all of the groups receiving aluminium, but it was less severe in resveratrol treated group. SOD and GPx levels in aluminium + resveratrol group were higher than in the aluminum group (p < 0.05). MDA level, as an index of lipid peroxidation, increased signifi cantly in all of the groups receiving aluminium. MDA level was lower in aluminium + resveratrol group compared to aluminum group and the difference was signifi cant (p < 0.05). CONCLUSIONS: This study suggests that resveratrol is effective in preventing AL induced toxicity by reducing MDA production in cerebral tissue. Resveratrol also attenuated SOD and GPx suppression in cerebral tissue signifi cantly. Our fi ndings provide the rationale for further studies directed to understanding the mechanism of resveratrol in preventing neurodeterioration. |
| Databáze: | OpenAIRE |
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