Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine
| Autor: | Michael Maes, Herbert Y. Meltzer, E. Bosmans |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Psychosis medicine.drug_class medicine.medical_treatment Atypical antipsychotic Inflammation immune system diseases Reference Values hemic and lymphatic diseases Internal medicine medicine Humans Interleukin 6 Clozapine Analysis of Variance biology Interleukin-6 Age Factors Interleukin Immunosuppression Receptors Interleukin-2 Receptors Interleukin Middle Aged medicine.disease Receptors Interleukin-6 female genital diseases and pregnancy complications Psychiatry and Mental health Endocrinology Schizophrenia biology.protein Female medicine.symptom Psychology medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0001-690X |
| Popis: | The purpose of this study was to investigate immune-inflammatory markers in schizophrenia and the effects of chronic treatment with clozapine, an atypical antipsychotic agent, on these variables. Toward this end, we measured interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and sIL-2R in the blood of 26 normal controls and 14 schizophrenic patients before and after treatment with clozapine. The sIL-2R and IL-6 levels were significantly higher in younger (35 years) schizophrenic subjects than in normal controls and older (or = 35 years) schizophrenic subjects. The sIL-6R levels were significantly lower in schizophrenic subjects than in normal controls. Chronic treatment with clozapine significantly increased the blood concentration of sIL-2R; the increases in the latter were significantly related to the dose of clozapine but not to changes in severity of positive or negative symptoms. We conclude that: (a) schizophrenia in younger people is accompanied by increased IL-6 and sIL-2R secretion; and (b) subchronic treatment with clozapine increases sIL-2R levels. Increased plasma sIL-2R may be one mechanism by which neuroleptics exhibit their immunosuppressive effects. |
| Databáze: | OpenAIRE |
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