Diet and sedentary behaviour in relation to cancer survival. A report from the national health and nutrition examination survey linked to the U.S. mortality registry
Autor: | Christine Taljaard-Krugell, H. Salome Kruger, Heinz Freisling, Michael F. Leitzmann, Marlien Pieters, Cristian Ricci, Inarie Jacobs, Cornelius M. Smuts |
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Přispěvatelé: | 29790514 - Ricci, Cristian, 10061568 - Kruger, Herculina Salome, 10797920 - Pieters, Marlien, 20924445 - Smuts, Cornelius Mattheus, 20085850 - Taljaard-Krugell, Christine, 24164399 - Jacobs, Inarie |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Vitamin Adult Male National Health and Nutrition Examination Survey Cancer survivors 030209 endocrinology & metabolism Riboflavin Critical Care and Intensive Care Medicine 03 medical and health sciences chemistry.chemical_compound Eating 0302 clinical medicine Cancer Survivors Environmental health Cause of Death Neoplasms Medicine Humans Vitamin B12 Registries Mortality Cause of death Aged Proportional Hazards Models Sedentariness 030109 nutrition & dietetics Nutrition and Dietetics business.industry Hazard ratio Middle Aged Micronutrient Nutrition Surveys United States Diet Human nutrition chemistry Linear Models Female Sedentary Behavior business Follow-Up Studies |
Zdroj: | Clinical nutrition (Edinburgh, Scotland). 39(11) |
ISSN: | 1532-1983 |
Popis: | Summary Background & aims Cancer is the second most common chronic disease and cause of death in the United States. Our aim was to evaluate the associations of sedentary behavior and nutrient intakes with total and cancer-specific mortality among US cancer survivors. Methods Data from 2371 cancer survivors collected by the US National Health and Nutrition Examination Survey between 1999 and 2014 were linked to the US mortality registry. Multivariable adjusted Cox proportional hazard models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for all-cause and cancer-specific mortality associated with sedentary time and nutrient intakes. The interaction between time spent on sedentary activities and nutrient intake was evaluated on additive and multiplicative scales. Results During a median observational period of 5.7 years, 532 total deaths occurred among cancer survivors, of which 180 were cancer-specific. A monotonic increasing linear relationship between time spent sitting and all-cause mortality was observed (HR = 1.15, 95% CI = 1.03, 1.28 per one standard deviation increment). The highest versus the lowest tertiles of intakes of dietary fiber, carotene, niacin, thiamine, riboflavin, vitamin B6, vitamin B12, and vitamin C were inversely associated with all-cause and cancer-specific mortality (HRs = 0.48 to 0.75). The inverse associations with all-cause mortality were more pronounced for combinations of low sedentary behaviour and high intakes of dietary fiber, carotenoids, vitamin B12, and vitamin C. Conclusion Our findings support recommendations for cancer survivors to reduce time spent sedentary and to follow a balanced diet with adequate intakes of dietary fiber and micronutrients. |
Databáze: | OpenAIRE |
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