Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia
| Autor: | Jang Kyu Lee, Jeong-Won Hong, Jae Woo Lee, Soyeong Jang, Il Suk Noh, Myung Ho Lim, Mi Yoo, Dae-bo Lee, Jong hyuk Choi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Leuprorelin medicine.medical_specialty Feminization (biology) media_common.quotation_subject Sexual Offenders 03 medical and health sciences 0302 clinical medicine Leuprolide Acetate Paraphilia medicine Humans 030212 general & internal medicine Psychiatry Adverse effect media_common Paraphilic Disorders business.industry Psychiatric assessment Sex Offenses Therapeutic effect General Medicine Criminals Middle Aged Sexual fantasy medicine.disease 030227 psychiatry Diagnostic and Statistical Manual of Mental Disorders Feeling Original Article Humanities & Forensic Medicine Leuprolide business medicine.drug |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| DOI: | 10.3346/jkms.2018.33.e231 |
| Popis: | Background This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment. Methods The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016. Results After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported. Conclusion These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy. Graphical Abstract |
| Databáze: | OpenAIRE |
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