An oxidatively releasable caging group that senses lipid peroxidation
| Autor: | Bruce P. Branchaud, Kari A. Trumbull |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Pharmaceutical Science Biosensing Techniques medicine.disease_cause Biochemistry Caged molecule Lipid peroxidation chemistry.chemical_compound Drug Discovery medicine Molecular Biology chemistry.chemical_classification Reactive oxygen species Autoxidation Organic Chemistry Methyl linoleate General Medicine Linoleic Acids Xanthenes chemistry Molecular Medicine lipids (amino acids peptides and proteins) Lipid Peroxidation Oxidation-Reduction Oxidative stress |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 15:5544-5547 |
| ISSN: | 0960-894X |
| Popis: | A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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