Treatment with Mesenchymal Stromal Cells Overexpressing Fas-Ligand Ameliorates Acute Graft-versus-Host Disease in Mice
| Autor: | Andrei Mircea Vacaru, Ana-Maria Mazilu, Madalina Dumitrescu, Ioana Madalina Fenyo, Anca Violeta Gafencu, Ana-Maria Vacaru |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Fas Ligand Protein
QH301-705.5 bone marrow transplantation T-Lymphocytes Gene Expression Graft vs Host Disease Severity of Illness Index Catalysis Article Immunophenotyping Inorganic Chemistry Mice graft versus host disease mesenchymal stromal cells FasL immunosuppression Animals Transplantation Homologous Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Organic Chemistry Hematopoietic Stem Cell Transplantation Disease Management Mesenchymal Stem Cells General Medicine Prognosis Computer Science Applications Chemistry Disease Models Animal surgical procedures operative Treatment Outcome Organ Specificity Disease Susceptibility Biomarkers Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 534 International Journal of Molecular Sciences, Vol 23, Iss 534, p 534 (2022) |
| ISSN: | 1422-0067 |
| Popis: | Allogeneic hematopoietic cell transplantation (allo-HCT) has the potential to cure malignant and non-malignant hematological disorders, but because of the serious side effects of this intervention its applications are limited to a restricted number of diseases. Graft-versus-host disease (GvHD) is the most frequent complication and the leading cause of mortality and morbidity following allo-HCT. It results from the attack of the transplanted T cells from the graft against the cells of the recipient. There is no clear treatment for this severe complication. Due to their immunomodulatory properties, mesenchymal stromal cells (MSC) have been proposed to treat GvHD, but the results did not meet expectations. We have previously showed that the immunomodulatory effect of the MSC was significantly enhanced through adenoviral-mediated overexpression of FasL. In this study, we have tested the properties of FasL-overexpressing MSC in vivo, in a mouse model for acute GvHD. We found that treatment with FasL-overexpressing MSC delayed the onset of the disease and increased survival of the mice. |
| Databáze: | OpenAIRE |
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