Characterization of Chalcones from Medicago sativa L. and Their Hypolipidemic and Antiangiogenic Activities
| Autor: | Ting Li, Qinge Ma, Rongrui Wei, Wen-Min Liu, Zhipei Sang, Song Zhongwen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Chalcone
Drug Evaluation Preclinical Positive control Angiogenesis Inhibitors Biology 01 natural sciences chemistry.chemical_compound Chalcones Botany Human Umbilical Vein Endothelial Cells Ic50 values medicine Humans Medicago sativa Hypolipidemic Agents Molecular Structure Traditional medicine 010405 organic chemistry Hep G2 Cells General Chemistry Plant Components Aerial In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Simvastatin Hepg2 cells Human umbilical vein endothelial cell General Agricultural and Biological Sciences medicine.drug |
| Zdroj: | Journal of Agricultural and Food Chemistry. 64:8138-8145 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.6b03883 |
| Popis: | Medicago sativa L. is the most important cultivated herbage, known as “the king of forage” and “feed queen”, in the world. A total of 8 new chalcones (1–8), and 12 known chalcones (9–20) were isolated from the aerial parts of M. sativa for the first time. Their structures were identified by extensive spectral data and references. The hypolipidemic and antiangiogenic activities of compounds (1–20) were evaluated for the first time. Compounds 3, 4, 11, 12, and 20 (10 μM) exhibited significant hypolipidemic activities by measuring the triglyceride content in HepG2 cells, with simvastatin as the positive control. Moreover, compounds 6, 8, 18, and 19 exhibited moderate antiangiogenic activities, which inhibited vascular-endothelial-growth-factor-induced human umbilical vein endothelial cell proliferation in vitro, with IC50 values of 13.86 ± 0.43, 15.53 ± 0.19, 39.52 ± 0.24, and 45.04 ± 0.51 μM, respectively. These research results may guide the search for new natural products with hypolipidemic and antiangiog... |
| Databáze: | OpenAIRE |
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