Absorption and Excretion of Ascorbic Acid Alone and in Acerola (Malpighia emarginata) Juice: Comparison in Healthy Japanese Subjects
| Autor: | Kenichi Nagamine, Shingo Aizawa, Naoki Maruyama, Takayuki Hanamura, Akihito Ishigami, Akiko Amano, Yoshitaka Kondo, Eriko Uchida, Hitoshi Aoki, Takeshi Koizumi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Pharmaceutical Science Ascorbic Acid Urine Intestinal absorption Beverages Excretion Food-Drug Interactions Young Adult Japan Reference Values Humans Ingestion Food science Flavonoids Pharmacology Dose-Response Relationship Drug Vitamin C Chemistry Area under the curve Vitamins General Medicine Ascorbic acid Bioavailability Intestinal Absorption Area Under Curve Fruit Plant Preparations Malpighiaceae |
| Zdroj: | Biological and Pharmaceutical Bulletin. 34:1744-1747 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.34.1744 |
| Popis: | It has been suggested that some food components, such as bioflavonoids, affect the bioavailability of ascorbic acid in humans. Since little is known in Japan about the effective intake of this dietary requirement, we tested young Japanese males after the ingestion of commercial ascorbic acid or acerola (Malpighia emarginata DC.) juice to compare the quantities absorbed and excreted. Healthy Japanese subjects received a single oral dose of ascorbic acid solution (50, 100, 200 or 500 mg) and received distilled water as a reference at intervals of 14 d or longer. All subjects were collected blood and urine until 6 h after ingestion and evaluated for time-dependent changes in plasma and urinary ascorbic acid levels. Predictably, the area under the curve (AUC) values in plasma and urine after ingestion increased dose-dependently. Next, each subject received diluted acerola juice containing 50 mg ascorbic acid. Likewise, their plasma and urinary ascorbic acid concentrations were measured. In plasma, the AUC value of ascorbic acid after ingestion of acerola juice tended to be higher than that from ascorbic acid alone. In contrast, the urinary excretion of ascorbic acid at 1, 2 and 5 h after ingestion of acerola juice were significantly less than that of ascorbic acid. These results indicate that some component of acerola juice favorably affected the absorption and excretion of ascorbic acid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|