Comparative study of two mechlorethamine, vincristine, procarbazine, and prednisone derived chemotherapeutic protocols for the management of pediatric Hodgkin lymphoma (HL): single-center 5-year experience

Autor:	Mohamed Sarhan, Mohamed Sedki, Ashraf Fouda, Youssef Al-Tonbary, Rasha El-Ashry, Emad Salama
Rok vydání:	2010
Předmět:	musculoskeletal diseases Toxic hepatitis Male Cancer Research medicine.medical_specialty Anthracycline Adolescent medicine.medical_treatment Single Center Procarbazine Prednisone Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Mechlorethamine Child Cyclophosphamide Survival analysis Chemotherapy business.industry Liver cell Cytarabine Infant Hematology Hodgkin Disease Survival Analysis Surgery Methotrexate Oncology Vincristine Child Preschool Egypt Female medicine.symptom business medicine.drug Follow-Up Studies
Zdroj:	Leukemialymphoma. 51(4)
ISSN:	1029-2403
Popis:	We aimed for the comparison of two protocols (OAP and COMP) as chemotherapy treatment in children with Hodgkin lymphoma (HL). A total of 119 children newly diagnosed with HD were divided to receive either the anthracycline-based OAP protocol or the alkylating-agent-based COMP protocol. Sixty patients received the OAP protocol and 59 patients received the COMP protocol. Complete response was achieved for 81.4% of patients treated with the COMP protocol versus 53.3% for those who received the OAP treatment. Toxic hepatitis or liver cell failure was recorded in 5% of patients treated with the COMP protocol. Complications were more frequent in those treated with the OAP protocol, as 6.8% developed heart failure and 20% showed toxic hepatitis or liver cell failure. The relapse rate was almost equal in both treatment arms. Patients treated with the COMP protocol achieved a better response and less toxicity but with similar survival to those given the OAP protocol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf8a2e9d0f7ec5de33d5ef9b2f91b76 https://pubmed.ncbi.nlm.nih.gov/20218813 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.