Enhancement of nonspecific resistance to microbial infections of synthetic lipid A-subunit analogues of GLA-27 modified at the C1 position of the glucosamine backbone
| Autor: | Mitsunobu Nakatsuka, Chiaki Nishimura, Akira Hasegawa, Yoshio Kumazawa, S. Ikeda, Makoto Kiso, J. Yuzuru Homma, Motohiro Matsuura |
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| Rok vydání: | 1990 |
| Předmět: |
Lipopolysaccharide
Immunology Biology medicine.disease_cause Microbiology Lipid A chemistry.chemical_compound Mice Structure-Activity Relationship Glucosamine Interferon medicine Vaccinia Animals Pseudomonas Infections Orthopoxvirus Pharmacology Mice Inbred ICR Pseudomonas aeruginosa biology.organism_classification Immunity Innate Killer Cells Natural chemistry Biochemistry Acetylation Phosphorylation Female Interferons medicine.drug |
| Zdroj: | International journal of immunopharmacology. 12(6) |
| ISSN: | 0192-0561 |
| Popis: | The C1 position of lipid A-subunit analogue GLA-27, 4-O- phosphono - D - gluxosamine carrying N -3-tetradecanoyloxytetradecanoyl(C 14 - O -(C 14 )) and 3- O -tetradecanoyl (C 14) groups, was S -acetylated, thiolated or phosphorylated. Enhancement of nonspecific resistance to Pseudomonas aeruginosa and vaccinia virus infections of these chemically modified compounds were investigated. Thiolation augmented the nonspecific resistance to P. aeruginosa infectiion. Protective activity against vaccinia virus infection was reduced by all the chemical modifications. NK cell activity was found not to be effected by S -acetylation, but to be decreased slightly by thiolation or phosphorylation. IFN-inducing activity was reduced remarkably by thiolation or S -acetylation, or completely diminished by phosphorylation, compared with that of GLA-27. |
| Databáze: | OpenAIRE |
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