The viewing of a ‘Bloodcurdling’ horror movie increases platelet reactivity: A randomized cross-over study in healthy volunteers
| Autor: | A.M. van Dijk, Mattijs E. Numans, C. Racca, Tobias Bonten, Abel Thijs, Wessel W. Fuijkschot, J.J.K. van Diemen, Yvo M. Smulders, T. Knol |
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| Přispěvatelé: | Internal medicine, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes, AII - Inflammatory diseases, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, Academic Medical Center |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Platelet Aggregation Motion Pictures Psychological Distress Platelet reactivity Young Adult Fear/physiology Internal medicine Healthy volunteers Clinical endpoint medicine Humans Platelet Platelet activation Platelet function test Cross-Over Studies business.industry Hematology Crossover study Healthy Volunteers Cardiovascular Diseases Fear/psychology Hemostasis Etiology Cardiology Female business |
| Zdroj: | Thrombosis Research, 182, 27-32. Elsevier Limited Thrombosis Research, 182, 27-32 van Diemen, J J K, van Dijk, A, Racca, C, Knol, T, Bonten, T N, Numans, M E, Fuijkschot, W W, Smulders, Y M & Thijs, A 2019, ' The viewing of a ‘Bloodcurdling’ horror movie increases platelet reactivity: A randomized cross-over study in healthy volunteers ', Thrombosis Research, vol. 182, pp. 27-32 . https://doi.org/10.1016/j.thromres.2019.07.028 Thrombosis research, 182, 27-32. Elsevier Limited |
| ISSN: | 0049-3848 |
| Popis: | Background Epidemiological studies have suggested an increased risk of cardiovascular events (CVE) during acute stressful and/or frightful moments. A possible explanation for this could be an effect of acute stress on hemostasis. A recent study demonstrated an increase in factor VIII after watching a horror movie. Primary hemostasis, however, is thought to play a more prominent role in the etiology of CVE. The objective of this study was therefore to assess the influence of viewing a ‘bloodcurdling’ horror movie on platelet reactivity in healthy volunteers. Methods We performed a randomized cross-over study in healthy adults. Subjects were allocated to two movies in random sequence: a horror and a control movie. Blood was drawn at baseline and after 24 min of viewing time. The primary endpoint was the change in Platelet Function Analyzer® Closure Time (Δ PFA-CT) after watching the movie. Results In total, 20 participants, aged 18–30 years, completed the study protocol. The delta PFA-CT was statistically significantly shorter with a mean in the delta difference of −9.7 s (SEM 4.0, 95% C.I. −18.0 to −1.3) during the horror movie versus the control movie. The Light Transmission Aggregometry endpoints were in line with the PFA-CT, albeit only the highest level of Arachidonic Acid agonist demonstrated a statistically significant mean difference in the delta of aggregation of 13.15% (SEM 7.0, 95% C.I. 1.6–27.9). Conclusion A ‘blood curdling’ horror movie increases platelet reactivity. These data are supportive of a role of platelet reactivity in acute stress induced cardiovascular event risk. |
| Databáze: | OpenAIRE |
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